Cooperation between the Hemagglutinin of Avian Viruses and the Matrix Protein of Human Influenza A Viruses
Identifieur interne : 001751 ( Main/Exploration ); précédent : 001750; suivant : 001752Cooperation between the Hemagglutinin of Avian Viruses and the Matrix Protein of Human Influenza A Viruses
Auteurs : Christoph Scholtissek ; Jürgen Stech ; Scott Krauss ; Robert G. WebsterSource :
- Journal of Virology [ 0022-538X ] ; 2002.
Descripteurs français
- KwdFr :
- Amantadine (pharmacologie), Animaux, Antiviraux (pharmacologie), Chiens, Glycoprotéine hémagglutinine du virus influenza (génétique), Glycoprotéine hémagglutinine du virus influenza (métabolisme), Grippe chez les oiseaux (virologie), Grippe humaine (virologie), Humains, Lignée cellulaire, Méthode des plages virales, Protéines de la matrice virale (génétique), Protéines de la matrice virale (métabolisme), Rein (cytologie), Rein (virologie), Résistance virale aux médicaments, Virus de la grippe A (), Virus de la grippe A (croissance et développement), Virus de la grippe A (génétique), Virus de la grippe A (métabolisme), Virus recombinants, Volaille.
- MESH :
- croissance et développement : Virus de la grippe A.
- cytologie : Rein.
- génétique : Glycoprotéine hémagglutinine du virus influenza, Protéines de la matrice virale, Virus de la grippe A.
- métabolisme : Glycoprotéine hémagglutinine du virus influenza, Protéines de la matrice virale, Virus de la grippe A.
- pharmacologie : Amantadine, Antiviraux.
- virologie : Grippe chez les oiseaux, Grippe humaine, Rein.
- Animaux, Chiens, Humains, Lignée cellulaire, Méthode des plages virales, Résistance virale aux médicaments, Virus de la grippe A, Virus recombinants, Volaille.
English descriptors
- KwdEn :
- Amantadine (pharmacology), Animals, Antiviral Agents (pharmacology), Cell Line, Dogs, Drug Resistance, Viral, Hemagglutinin Glycoproteins, Influenza Virus (genetics), Hemagglutinin Glycoproteins, Influenza Virus (metabolism), Humans, Influenza A virus (drug effects), Influenza A virus (genetics), Influenza A virus (growth & development), Influenza A virus (metabolism), Influenza in Birds (virology), Influenza, Human (virology), Kidney (cytology), Kidney (virology), Poultry, Reassortant Viruses, Viral Matrix Proteins (genetics), Viral Matrix Proteins (metabolism), Viral Plaque Assay.
- MESH :
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus, Viral Matrix Proteins.
- chemical , metabolism : Hemagglutinin Glycoproteins, Influenza Virus, Viral Matrix Proteins.
- chemical , pharmacology : Amantadine, Antiviral Agents.
- cytology : Kidney.
- drug effects : Influenza A virus.
- genetics : Influenza A virus.
- growth & development : Influenza A virus.
- metabolism : Influenza A virus.
- virology : Influenza in Birds, Influenza, Human, Kidney.
- Animals, Cell Line, Dogs, Drug Resistance, Viral, Humans, Poultry, Reassortant Viruses, Viral Plaque Assay.
Abstract
To analyze the compatibility of avian influenza A virus hemagglutinins (HAs) and human influenza A virus matrix (M) proteins M1 and M2, we doubly infected Madin-Darby canine kidney cells with amantadine (1-aminoadamantane hydrochloride)-resistant human viruses and amantadine-sensitive avian strains. By using antisera against the human virus HAs and amantadine, we selected reassortants containing the human virus M gene and the avian virus HA gene. In our system, high virus yields and large, well-defined plaques indicated that the avian HAs and the human M gene products could cooperate effectively; low virus yields and small, turbid plaques indicated that cooperation was poor. The M gene products are among the primary components that determine the species specificities of influenza A viruses. Therefore, our system also indicated whether the avian HA genes effectively reassorted into the genome and replaced the HA gene of the prevailing human influenza A viruses. Most of the avian HAs that we tested efficiently cooperated with the M gene products of the early human A/PR/8/34 (H1N1) virus; however, the avian HAs did not effectively cooperate with the most recently isolated human virus that we tested, A/Nanchang/933/95 (H3N2). Cooperation between the avian HAs and the M proteins of the human A/Singapore/57 (H2N2) virus was moderate. These results suggest that the currently prevailing human influenza A viruses might have lost their ability to undergo antigenic shift and therefore are unable to form new pandemic viruses that contain an avian HA, a finding that is of great interest for pandemic planning.
Url:
DOI: 10.1128/JVI.76.4.1781-1786.2002
PubMed: 11799173
PubMed Central: 135889
Affiliations:
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Le document en format XML
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Webster</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="2002">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amantadine (pharmacology)</term><term>Animals</term><term>Antiviral Agents (pharmacology)</term><term>Cell Line</term><term>Dogs</term><term>Drug Resistance, Viral</term><term>Hemagglutinin Glycoproteins, Influenza Virus (genetics)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (metabolism)</term><term>Humans</term><term>Influenza A virus (drug effects)</term><term>Influenza A virus (genetics)</term><term>Influenza A virus (growth & development)</term><term>Influenza A virus (metabolism)</term><term>Influenza in Birds (virology)</term><term>Influenza, Human (virology)</term><term>Kidney (cytology)</term><term>Kidney (virology)</term><term>Poultry</term><term>Reassortant Viruses</term><term>Viral Matrix Proteins (genetics)</term><term>Viral Matrix Proteins (metabolism)</term><term>Viral Plaque Assay</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Amantadine (pharmacologie)</term><term>Animaux</term><term>Antiviraux (pharmacologie)</term><term>Chiens</term><term>Glycoprotéine hémagglutinine du virus influenza (génétique)</term><term>Glycoprotéine hémagglutinine du virus influenza (métabolisme)</term><term>Grippe chez les oiseaux (virologie)</term><term>Grippe humaine (virologie)</term><term>Humains</term><term>Lignée cellulaire</term><term>Méthode des plages virales</term><term>Protéines de la matrice virale (génétique)</term><term>Protéines de la matrice virale (métabolisme)</term><term>Rein (cytologie)</term><term>Rein (virologie)</term><term>Résistance virale aux médicaments</term><term>Virus de la grippe A 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xml:lang="en"><p>To analyze the compatibility of avian influenza A virus hemagglutinins (HAs) and human influenza A virus matrix (M) proteins M1 and M2, we doubly infected Madin-Darby canine kidney cells with amantadine (1-aminoadamantane hydrochloride)-resistant human viruses and amantadine-sensitive avian strains. By using antisera against the human virus HAs and amantadine, we selected reassortants containing the human virus M gene and the avian virus HA gene. In our system, high virus yields and large, well-defined plaques indicated that the avian HAs and the human M gene products could cooperate effectively; low virus yields and small, turbid plaques indicated that cooperation was poor. The M gene products are among the primary components that determine the species specificities of influenza A viruses. Therefore, our system also indicated whether the avian HA genes effectively reassorted into the genome and replaced the HA gene of the prevailing human influenza A viruses. Most of the avian HAs that we tested efficiently cooperated with the M gene products of the early human A/PR/8/34 (H1N1) virus; however, the avian HAs did not effectively cooperate with the most recently isolated human virus that we tested, A/Nanchang/933/95 (H3N2). Cooperation between the avian HAs and the M proteins of the human A/Singapore/57 (H2N2) virus was moderate. These results suggest that the currently prevailing human influenza A viruses might have lost their ability to undergo antigenic shift and therefore are unable to form new pandemic viruses that contain an avian HA, a finding that is of great interest for pandemic planning.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Krauss, Scott" sort="Krauss, Scott" uniqKey="Krauss S" first="Scott" last="Krauss">Scott Krauss</name><name sortKey="Scholtissek, Christoph" sort="Scholtissek, Christoph" uniqKey="Scholtissek C" first="Christoph" last="Scholtissek">Christoph Scholtissek</name><name sortKey="Stech, Jurgen" sort="Stech, Jurgen" uniqKey="Stech J" first="Jürgen" last="Stech">Jürgen Stech</name><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. 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